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Debbie Polisky, MS, MBA

SAMe – Supplement your Mood

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Dear Friends,

Do you ever feel this way?

They have diagnosed me with depression. I know I feel depressed, lost, not able to function… When we lost our focus, it’s difficult to know how to continue. I want natural options not drugs, drugs, and more drugs.

SAMe, short for S-adenosyl methionine is a natural compound found in all living cells and involved in over 35 biochemical processes in the body. It helps regulate the expression of genes. It assists in the action of several hormones and neurotransmitters, including serotonin, melatonin, dopamine and adrenaline. It’s also vital for normal brain functioning.

Depression and low SAMe

A low blood level of SAMe correlates with depression. Discovered in Europe in 1952, it has been studied for 20 years and used for depression and arthritis. SAMe may be used for depression for patients who haven’t responded to other antidepressant medications.

B-Vitamins and Depression

Mental well-being depends on several essential nutrients, including vitamins, minerals and fatty acids. Recent investigations with multi-ingredient formulas, such as the B-complex vitamins correlate positively with lower levels of depression. Low folate and B 12 have been associated with modulating mood disorders, depression, cognitive and social functioning. Choline, a nutrient widely found in foods such as fruit, vegetables, meat, eggs, cereal, dairy, decreased mood symptoms in patients with bipolar disorders. Serezec Plus contains a B-vitamin complex that assists in producing and “recycling” SAMe.

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Lack of Protein Rich Foods and Depression

Neurotransmitters, the brain’s chemical messengers can be affected by depression when there is an amino acid deficit, such as low levels of SAMe. This essential amino acid is found in high-protein foods such as meats and fish. Decreased levels of the neurotransmitter serotonin can produce numerous mental diseases, including depression, anxiety or social phobia.

What is the research behind SAMe?

Richard P.Brown, MD, associate professor of clinical psychiatry at Columbia University College of Physicians and Surgeons and co-author of Stop Depression Now: the Breakthrough Supplement that Works as Well as Prescription Drugs in Half the Time…With No Side Effects has been treating patients with SAMe with positive results.

Europe and SAMe

Although SAMe has been on the US market since 1999, it was discovered in Italy, studied for decades and approved as a prescription drug in Europe. The first clinical study of its use for depression was not completed until the 1970s (Agnoli et al, 1976).

Teodoro Bottiglieri, PhD, director of neuropharmacology and senior research scientist at Baylor University’s Institute for Metabolic Disease, found, in research studies, lower than normal levels of SAMe in cerebrospinal fluid in some patients with depression, dementia, Alzeimer’s disease and disorders of folate metabolism.

As research continues in this area, since 1988, studies using higher doses of SAMe have shown it’s efficacy in treating major depression (Bressa, 1994; Delle Chiaie and Boissard, 1997, Delle Chiaie et al, 2000), depression secondary to a medical illness, postmenopausal depressions and treatment-resistant depression.

Share your Comments:

What supplements do you use for your depression?

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About Debbie

Debbie Polisky, MS, MBA, CLT is a Bilingual Nutritionist, Zumba Instructor, Wellness Consultant and Adjunct Faculty who uses mind and body techniques, such as mindfulness, stress management, exercise, dance/zumba, yoga and nutrition to improve the lives of patients, students and the community. She has over 20 years of experience in the healthcare field, in two countries, Argentina and in USA and in her two native languages, English and Spanish.

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